Ubushinwa butanga Sarms Raw Sr9009 Stenabolic API

REV-ERBα na REV-ERBβ ibyakirwa na kirimbuzi ni repressors transcriptional ihuza injyana ya circadian ninzira ya metabolike muburyo bushingiye kuri heme.SR9009 ni agoniste ya REV-ERB yongerera ihindagurika ryimikorere ya gen igengwa na REV-ERBα na REV-ERBβ hamwe na IC50 ifite agaciro ka 670 na 800 nM.1Binyuze mu gukora REV-ERB, SR9009 yerekanwe kugabanya ibikorwa bya moteri ya circadian mugihe cyumwijima no guhindura imiterere ya genes yibanze yisaha muri hypothalami yimbeba.1Uburyo bwa circadian bwerekana imiterere ya genes nyinshi za metabolike mu mwijima, imitsi ya skeletale na tipusi ya adipose nazo zerekanwe ko zahinduwe mu mbeba zagaragaye kuri SR9009, bigatuma ingufu zikoreshwa.1 Imbeba zifite umubyibuho ukabije ziterwa nimirire zavuwe hamwe na mg / kg 100 SR9009 (ip inshuro ebyiri kumunsi muminsi 30) byavuzwe ko igabanya ibinure byagabanutse kandi byaragaragaye cyane dyslipidemiya na hyperglycemia.1

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