Adipotide inshinge 2mg
NikiAdipotide?
Adipotide (bita FTPP cyangwa peptide protapototic) yica selile zibyibushye, byoroshye kandi byoroshye, muguhitamo gutanga amaraso muri selile.Igishimishije, adipotide ibasha kumenya imiyoboro yamaraso iri mu ngirabuzimafatizo ziva mu mitsi y’amaraso mu mubiri wose bityo ikaba ihitamo cyane.Ubushakashatsi bwakozwe ku nguge bwerekana ko adipotide idatera ibiro gusa, ahubwo itera insuline kandi ikuraho zimwe mu ngaruka za diyabete yo mu bwoko bwa 2.
Ikoreshwa ryibicuruzwa: IYI PRODUCT YATANZWE NUBUSHAKASHATSI BUSHAKA GUSA.Iri zina ryemerera gukoresha imiti yubushakashatsi cyane mugupima vitro no kugerageza laboratoire gusa.Ibicuruzwa byose biboneka kururu rubuga bigamije uburezi gusa.Kwinjiza umubiri muburyo ubwo aribwo bwose mu bantu cyangwa ku nyamaswa birabujijwe n'amategeko.Iki gicuruzwa kigomba gukoreshwa gusa nababifitemo uruhushya, babishoboye.Iki gicuruzwa ntabwo ari ibiyobyabwenge, ibiryo, cyangwa kwisiga kandi ntibishobora gukoreshwa nabi, gukoreshwa nabi cyangwa kuyobya ibiyobyabwenge, ibiryo cyangwa kwisiga.
Imiterere ya Adipotide
Urukurikirane: Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys - Gly-Gly– (Lys-Leu-Ala-Lys-Leu-Ala-Lys) 2
Inzira ya molekulari: C152H252N44O42
Uburemere bwa molekuline: 2611.41 g / mol
Adipotide no Gutakaza Ibinure
Adipotide yakozwe kandi ishyirwa mu cyiciro cya mbere cy’amavuriro mu mwaka wa 2011 kugira ngo ikore ubushakashatsi ku bushobozi ifite bwo kwica selile.Ubushakashatsi bwakozwe ku nguge ya rhesus bwerekanye ko adipotide itera apoptose yibasira mumitsi yamaraso yumubiri wera (ibinure).Hatabayeho gutanga amaraso, ingirabuzimafatizo zarapfuye.Igisubizo cyagaragaye ni ugutakaza ibiro byihuse, kugabanuka byihuse mubipimo byumubiri (BMI), no kunoza imiterere ya insuline.Igishimishije, kuvura hamwe na adipotide hamwe no gutakaza ibinure nyuma ntabwo byongereye ibiro gusa, ahubwo mubyukuri byagize uruhare mubihinduka mumyitwarire yo kurya.Inkende zatakaje ibiro hamwe na adipotide nazo zagaragaje kugabanuka kw'ibyo kurya [1].
A. Kugabanuka kw'ijana kumatsinda yo kugenzura (ubururu) hamwe nabavuwe na adipotide (dosiye ebyiri zitandukanye, zerekanwa mumutuku)
B. Kugabanuka kw'ijana muri BMI (kugenzura no kuvura)
A. Erekana impinduka mubisabwa bya insuline (agace kari munsi yumurongo) kubuvuzi (umutuku) no kugenzura (ubururu) amatsinda.AUC yabazwe uhereye ku kizamini cya IVGTT.
B. Yerekana insuline ya insulineque mbere na nyuma yo kuvura (umutuku) no kugenzura (ubururu) amatsinda.Amatsinda avuwe yerekana kugabanuka gukabije kwa insuline.
C. Guhindura imikoreshereze ya biscuit mumiti ivurwa (umutuku) no kugenzura (ubururu) mumatsinda.
Intego ya adipotide kumitsi yamaraso ikora selile zirashobora guhuzwa na proteine reseptor yitwa banitin.Prohibitine ni poroteyine ya membrane ishobora kuboneka gusa mu mitsi y'amaraso ikora amavuta yera no muri selile.Byerekanwe ko adipotide ifatanya niyi poroteyine [2].Niba bigaragaye ko banitin iboneka gusa mu mavuta ya vasulature na kanseri ya kanseri, noneho gupima adipotide bizaba bishinzwe kumenya intego yihariye y’ibinure ishobora gukoreshwa atari mu rwego rwo kuvura gusa, ahubwo no mu rwego rwo gusuzuma.
Prohibitin-yibasira peptide 1 (izwi kandi nka banitin-TP01 na TP01; izina ry'ubucuruzi Adipotide) ni peptidomimetike hamwe na CKGGRAKDC-GG-D (KLAKLAK) 2.Numuti wa proapoptotique wubushakashatsi wagaragaye ko utera ibiro byihuse imbeba ninguge za rhesus.Uburyo bwibikorwa byabwo ni uguhitamo imiyoboro yihariye yamaraso itanga adipose tissue yamaraso, bigatuma imiyoboro igabanuka hamwe ningirangingo zamavuta zagaburiwe nizo mitsi kugira apoptose.TP01 yagenewe guhuza reseptor ebyiri, ANXA2 na banitin, zihariye imiyoboro y'amaraso itanga inyama za adipose yera.
ICYITONDERWA
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