Tirzepatide （mounjaro） 5mg 10mg 15mg inshinge

Tirzepatide

Tirzepatide ni iperereza rimwe mu cyumweru, glucose-iterwa na insulineotropique polypeptide na glucagon-isa na peptide-1 reseptor agonist ihuza ibikorwa bya incretine zombi muri molekile imwe.

Tirzepatide Yigana Hormone Kamere Yirera Yuzuye
Tirzepatide ikora yigana imisemburo ya GLP-1 na GIP isanzwe isohoka mu mara nyuma yo kurya, itera gusohora insuline.Igabanya kandi ubushake bwo gutinda kugabanya igihe bifata igifu ubusa kandi igahuza nu gice cyubwonko kibamo reseptor ya GLP-1 kugirango yerekane guhaga.

Tirzepatide ni imiti yubuvuzi yemewe na FDA yemerewe kuvura diyabete yo mu bwoko bwa 2.Urebye imbaraga zo kugabanya ibiro,tirzepatidegukoreshwa hanze-label yo kuvura umubyibuho ukabije.Ikora nka kabiri ya GLP-1 agonist na GIP agonist kugirango yunguke byinshi bisa nibigaragara hamwe n'imiti ya GLP-1 nka semaglutide.Kugeza ubu ishyirwa mu bikorwa nk'imiti ya kabiri ya diyabete, isa n'imiti ya GLP-1, kandi itangwa nk'inshuro imwe mu cyumweru inshinge.

Tirzepatide ni glucose iterwa na glucose ya insuline ya polypeptide (GIP) hamwe na glucagon imeze nka peptide-1 (GLP-1) resepto agonist, ikaba FDA yemerewe kuvura indwara ya diyabete yo mu bwoko bwa 2.Ni ngombwa kumenya ko tirzepatide itemewe kuvura indwara ya diyabete yo mu bwoko bwa 1 kandi itigeze ikorerwa ubushakashatsi ku barwayi barwaye pancreatite.Tirzepatide ni reseptor ya GIP na GLP-1 reseptor agonist, biganisha ku kurwanya cyane glycemic mu barwayi ba diyabete yo mu bwoko bwa 2 no kugabanya ibiro.

FDA yemeye Tirzepatide muri Gicurasi 2022. Tirzepatide irashobora kandi gukoreshwa hanze ya label yo kuvura umubyibuho ukabije.Kugeza ubu ishyirwa mubikorwa nkumuti wa kabiri wa diyabete, isa na GLP-1 imiti nka semaglutide.Numuti rimwe-mucyumweru imiti yatewe inshinge hamwe niyongera ryiyongera.

Amakuru yubuvuzi agezweho yerekanye ko tirzepatide iruta placebo mugutezimbere urwego rwa hemoglobine A1C.Igeragezwa rya SURPASS-5 ryerekanye ko -2,11% byagabanutse ku gipimo cya hemoglobine A1C kuri 5mg buri cyumweru, ugereranije na -0.86% hamwe na placebo.Ku kigero kinini cya mg 15 mu cyumweru, tirzepatide yatumye kugabanuka kwa -2.34% muri hemoglobine A1C.Ibi byerekanwe mu byumweru 40.Kugabanya ibiro 5.4 kg byagaragaye hamwe na 5mg ya tirzepatide, naho kugabanuka kwa kg 10,5 byagaragaye hamwe na mg 15.Iyi dose iterwa no kugabanya ibiro bisa na semaglutide, imiti isanzwe ya GLP-1 ikoreshwa mugucunga ibiro.

Ugereranije, tirzepatide yerekanwe gukora nkimiti ya GLP-1 ariko ifite akamaro kanini.Urebye uburyo bwo kugabanya ibiro no kubura uburozi bwumwijima, birashoboka ko bizagira uruhare rutaziguye mu kuvura indwara y’umwijima y’umwijima (NAFLD).

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