Gutakaza Ibiro Byinshi kuri Tirzepatide Ihuza Ibintu Birindwi

Mu bantu 3188 barwaye diyabete yo mu bwoko bwa 2 bubahirije gahunda ya tirzepatide (Mounjaro, Lilly) mu bigeragezo bine by'ingenzi byakozwe na agent, kimwe cya kane cyageze nibura ku gipimo cya 15% bivuye ku buremere bw'umubiri fatizo nyuma y'ibyumweru 40-42 bivurwa, n'abashakashatsi basanze impinduka zirindwi zifatizo zahujwe cyane no kuba hejuru yuru rwego rwo kugabanya ibiro.

Abanditsi bagize bati: "Ubu bushakashatsi bufasha kumenya abantu barwaye diyabete yo mu bwoko bwa 2 bakunze kugera ku kugabanya ibiro byinshi mu mubiri hamwe n’impamvu ziterwa n’umutima ziterwa na tirzepatide".

UBURYO:

• Abashakashatsi bakoze isesengura ryihuse ryamakuru yakusanyijwe ku bantu 3188 barwaye diyabete yo mu bwoko bwa 2 bari barubahirije gahunda ya tirzepatide bashinzwe mu byumweru 40-42 muri kimwe mu bigeragezo bine by'ingenzi byakozwe na agent: SURPASS-1, SURPASS- 2, SURPASS-3, na SURPASS-4.
• Abashakashatsi bagamije kumenya abahanura kugabanuka k'uburemere bw'umubiri byibuze 15% hamwe no kuvura tirzepatide kuri kimwe muri bitatu byapimwe - 5 mg, 10 mg, cyangwa mg 15 - byakoreshwaga no gutera inshinge rimwe mu cyumweru.
• Ibigeragezo uko ari bine byatanze amakuru yabujije kuvura icyarimwe byafasha kugabanya ibiro, kandi abantu bashyizwe mu isesengura ntibabonye imiti yo gutabara yo kurwanya glycemia.
• Igipimo cyibanze cyibanze muri ubwo bushakashatsi uko ari bune ni ubushobozi bwa tirzepatide yo kunoza igenzura rya glycemic (ryapimwe nurwego rwa A1c) ugereranije na placebo, semaglutide (Ozempic) 1 mg SC rimwe mu cyumweru, insuline degludec (Tresiba, Novo Nordisk), cyangwa insuline glargine ( Basaglar, Lilly).

FATA:

• Mu bantu 3188 bakomeje gukurikiza gahunda ya tirzepatide mu byumweru 40-42, 792 (25%) bagabanutse ibiro byibura 15% bivuye ku murongo fatizo.
• Isesengura ryinshi ryibanze kuri covariates ryerekanye ko ibyo bintu birindwi byari bifitanye isano cyane no kugabanya ibiro ≥15%: ikinini cya tirzepatide, kuba igitsina gore, kuba ubwoko bwabazungu cyangwa Aziya, kuba muto, kuvurwa na metformin, kugira imiti myiza ya glycemic (ishingiye kuri A1c yo hepfo no kwiyiriza ubusa serumu glucose), no kugira urwego rwa cholesterol ya lipoprotein idafite ubukana buke.
• Mugihe cyo gukurikirana, kugerwaho byibuze 15% kugabanya ibiro byibanze byumubiri byagize uruhare runini mukugabanuka kwinshi muri A1c, kwiyiriza ubusa serumu glucose, kuzenguruka mu rukenyerero, umuvuduko wamaraso, urwego rwa triglyceride, hamwe na serumu yumwijima enzyme alanine transaminase .
  

  MU BIKORWA:

  Yakomeje agira ati: "Ubu bushakashatsi bushobora gutanga amakuru y’ingirakamaro ku bavuzi n’abantu barwaye diyabete yo mu bwoko bwa 2 ku bijyanye n’uko bishoboka ko bagabanya ibiro byinshi by’umubiri hamwe na tirzepatide, kandi binafasha kwerekana ibimenyetso bishobora kuba byiza bigaragara mu bipimo bitandukanye by’indwara ziterwa n’umutima hamwe no kugabanya ibiro bya tirzepatide. , ”Abanditsi bashoje muri raporo yabo.