Semaglutide ni polypeptide abaganga bategeka kuvura diyabete yo mu bwoko bwa 2.FDA yemeye gukoresha Ozempic ya Novo Nordisk na Rybelsus nk'inshinge rimwe mu cyumweru cyangwa nk'ibinini.Gutera inshuro imwe mu cyumweru ya semaglutide hamwe nizina rya Wegovy byemewe vuba aha nkumuti wo kugabanya ibiro.
Ubushakashatsi bushya bwatanzwe muri Kongere yu Burayi yuyu mwaka ku mubyibuho ukabije (ECO2023, Dublin, 17-20 Gicurasi) bwerekana ko semaglutide y’ibiyobyabwenge bifite umubyibuho ukabije mu kugabanya ibiro mu bushakashatsi bwinshi, bumaze umwaka 1 ku isi.Ubushakashatsi bwakozwe na Dr Andres Acosta na Dr Wissam Ghusn, Ubuvuzi bwa Precision for Programme Umubyibuho ukabije ku ivuriro rya Mayo, Rochester, MN, Amerika na bagenzi be.
Semaglutide, glucagon imeze nka peptide-1 (GLP-1) reseptor agonist, niwo muti uherutse kwemezwa na FDA wo kurwanya umubyibuho ukabije.Yerekanye ingaruka zikomeye zo kugabanya ibiro mubigeragezo byinshi byigihe kirekire byateguwe nubuvuzi bwigihe gito.Nyamara, bike bizwi kubyerekeranye no kugabanya ibiro hamwe nibipimo bya metabolike biva mubikorwa byo hagati yisi-nyayo.Muri ubu bushakashatsi, abanditsi basuzumye ibyavuye mu kugabanya ibiro bifitanye isano na semaglutide ku barwayi bafite umubyibuho ukabije n'umubyibuho ukabije hamwe na diyabete yo mu bwoko bwa 2 (T2DM) mu mwaka 1 bakurikiranye.
Bakoze amakuru yisubiraho, menshi (Ibitaro bya Mayo Clinic: Minnesota, Arizona, na Florida) ikusanyamakuru ryerekeye ikoreshwa rya semaglutide mu kuvura umubyibuho ukabije.Harimo abarwayi bafite indangagaciro z'umubiri (BMI) kg27 kg / m2 (umubyibuho ukabije hamwe n'ibyiciro byose byo hejuru bya BMI) bandikwaga inshinge za semaglutide buri cyumweru (dosiye 0.25, 0.5, 1, 1.7, 2, 2.4mg; icyakora benshi bari kuri urugero rwo hejuru 2.4mg).Bakuyemo abarwayi bafata indi miti igabanya umubyibuho ukabije, abafite amateka yo kubaga umubyibuho ukabije, abafite kanseri, n'abari batwite.
Ingingo yibanze yanyuma yari igipimo cyo kugabanya ibiro (TBWL%) kumwaka 1.Icyiciro cya kabiri cyanyuma cyarimo igipimo cy’abarwayi bagera kuri ≥5%, ≥10%, ≥15%, na ≥20% TBWL%, guhindura ibipimo bya metabolike n’umutima nimiyoboro y'amaraso (umuvuduko w'amaraso, HbA1c [glycated hemoglobine, igipimo cyo kugenzura isukari mu maraso], kwiyiriza ubusa glucose hamwe namavuta yamaraso), TBWL% yabarwayi bafite T2DM kandi badafite, ninshuro zingaruka mbi mugihe cyambere cyo kuvura.
Abarwayi 305 bose bashyizwe mu isesengura (abagore 73%, bivuze imyaka 49, 92% byera, bivuze BMI 41, 26% hamwe na T2DM).Ibiranga ibyingenzi hamwe nubuyobozi bwo gusura ibisobanuro birambuye bigaragara mu mbonerahamwe ya 1 yuzuye.Muri cohort yose, hagati ya TBWL% yari 13.4% kumwaka 1 (kubarwayi 110 bafite amakuru yuburemere kumwaka 1).Abarwayi bafite T2DM bari bafite TBWL yo hasi ya 10.1% ku barwayi 45 kuri 110 bafite imibare mu mwaka 1, ugereranije n'abafite T2DM ya 16.7% kuri 65 ku barwayi 110 bafite amakuru ku mwaka 1.
Ijanisha ry'abarwayi batakaje hejuru ya 5% by'uburemere bw'umubiri wabo bari 82%, abarenga 10% bari 65%, abarenga 15% bari 41%, naho abarenga 20% bari 21% mu mwaka umwe.Kuvura Semaglutide kandi byagabanije cyane umuvuduko wamaraso wa systolique na diastolique kuri 6.8 / 2,5 mmHg;cholesterol yose hamwe na 10.2 mg / dL;LDL ya 5.1 mg / dL;na triglyceride ya 17,6 mg / dL.Kimwe cya kabiri cy'abarwayi bahuye n'ingaruka zijyanye no gukoresha imiti (154/305) aho bivugwa cyane ni isesemi (38%) na diyare (9%) (Ishusho 1D).Ingaruka mbi ahanini zoroheje ntabwo zagize ingaruka ku mibereho ariko mubihe 16 byavuyemo guhagarika imiti.
Abanditsi banzuye bagira bati: “Semaglutide yagize uruhare runini mu kugabanya ibiro ndetse no guhindura ibipimo bya metabolike mu mwaka 1 mu bushakashatsi bwakozwe ku mbuga nyinshi ku isi, bugaragaza akamaro kabwo mu kuvura umubyibuho ukabije, ku barwayi bafite T2DM cyangwa badafite.”
Itsinda rya Mayo ririmo gutegura izindi nyandiko zandikishijwe intoki zijyanye na semaglutide, harimo n’ibisubizo by’uburemere ku barwayi bongeye kugaruka nyuma yo kubagwa ibibari;ibisubizo byo kugabanya ibiro ku barwayi bari ku yindi miti igabanya umubyibuho ukabije ugereranije n’abatari bo.
Igihe cyo kohereza: Nzeri-20-2023