Niki NAD + Kandi irashobora rwose 'Guhindura' gusaza?

Nuburozi buto coenzyme ituma imibiri yacu yikubita hejuru.Dore uko NAD + ikora n'impamvu abantu benshi babibona nk'inzira yo kurwanya gusaza.

Kubera ko isoko ryo kurwanya ryateye imbere mu myaka yashize, abahanga mu bya siyansi bagiye bashakisha ibintu byose bishobora gutinda cyangwa no guhindura ingaruka zo gusaza.Akenshi ibisubizo byabo bibeshya mugushakisha ibintu bihinduka uko dusaza, kandi kimwe mubyingenzi muribi cyabaye NAD +.Ibi byagaragaye mumibare yiyongera yinyongera irwanya gusaza ishaka guteza imbere kuramba - ariko iyo umaze gusiba munsi yimpuha hari ikintu cyo kwishimira rwose?Dore icyo NAD + aricyo, uko ikora n'impamvu ari ngombwa kumubiri wawe no kubuzima bwawe.

NAD + ni iki?

Mugihe tugenda dusaza, umubiri wacu utakaza ibintu na molekile zimwe na zimwe zishobora kuba ingenzi mu gukomeza kuba muto.Kimwe muri ibyo ni nicotinamide adenine dinucleotide, izwi cyane nka NAD +.

Abahanga mu bya siyansi babanje guhisha ko NAD + yabayeho mu 1906. Kuva icyo gihe, imyumvire yacu yagutse.Byagaragaye cyane kukazi mu ngirabuzimafatizo z'abantu, inyamaswa, ibimera ndetse n'umusemburo ukomeza ibintu byose neza.

NAD + ni coenzyme ikomeye ishobora kuboneka muri selile zose z'umubiri wawe.Ikora imirimo ibiri yingenzi - guhindura intungamubiri imbaraga kandi ni umukinnyi wingenzi mubikorwa byo guhinduranya, akora nkumufasha muto winshuti mugutunganya indi mikorere ya selile.

Irakora neza nkabatwara ibintu bito bimura electroni kuva kuri molekile ikajya mubindi kugirango ikore ibintu byose byerekana.Kuruhande rwindi molekile, NADH, igira uruhare mubitekerezo byinshi bitanga ingufu muri selile.Ifasha kandi kugenzura injyana yacu ya circadian iyobora ibitotsi byacu / kubyuka.

Yavumbuwe bwa mbere mu 1906 naHarden na Youngnkibigize kuzamura igipimo cya fermentation yinzoga mumisemburo.Kuva icyo gihe, imyumvire yacu yagutse cyane, kandi yakoreshejwe mukurwanya indwara nyinshi.

Kuki NAD + ari ngombwa

NAD + ni igushoboza, cyangwa lisansi, kubindi molekile zifasha umubiri gukora neza.Iyo urwego rugabanutse, ibikorwa bya enzymes iyo ari yo yose ya NAD (H) biterwa na fosifori ya okiside, TCA cycle, na glycolysis birabangamirwa.

Ibi bivamo umusaruro muke wa ATP.Irashobora kandi kugira ingaruka kurwego rwa PARP na sirtuins kandi biganisha ku kudakora kwinzira zimwe na zimwe za molekile zimanuka zigira uruhare mugusana ADN.

Muyandi magambo, bitabaye ibyo umubiri wacu ntukora neza nkuko washoboye, ntabwo ukora neza mukwisana kandi biganisha kumuvuduko wa metabolike.Hatariho NAD + ikora nka tagisi yingenzi, selile zawe zizabyara imbaraga nke umubiri ukeneye kugirango ubeho kandi ukore imirimo yawo.

Akamaro ka NAD + rero, ntigakomoka kubintu byose byubumaji, ahubwo ni ubushobozi bwayo bwo gufasha izindi molekile zingirakamaro gukora akazi kazo.Niba twarebaga umubiri nkikipe yumupira wamaguru, NAD + yaba umukinnyi wo hagati hagati, agakora ibishoboka kandi agatanga gutunga bifasha ba rutahizamu gushyira umupira murushundura.

Ntabwo ari flash, ntabwo yerekana ariko utayifite, ibikorwa byose biratandukana.Izo molekile zifite akamaro kanini mu gusana selile, kunoza metabolisme no kugenzura imikorere yibinyabuzima.Bitabaye ibyo, dushobora kwibonera aumubare wibibazo byubuzima.

Inyungu zo mumutwe za NAD + kuvura

Kimwe mu bimenyetso biranga gusaza ni ugutakaza imikorere yubwenge.Ukunda kwibagirwa ibintu, ukagira ikibazo cyo gutumbira, kandi ukumva ubwonko bwawe ari ibicu cyangwa igihu.Ubuvuzi bwa NAD busimbuza coenzyme ikenewe kugirango itinde cyangwa ihagarike iterambere ryiri gabanuka.Uzagira:

• Kongera ubwenge mu mutwe
• Kwibuka neza
• Kwibanda cyane
• Imyumvire myiza
• Ubuhanga bwiza bwo gukemura ibibazo

Imbaraga mumikorere yubwonko ukura mubuvuzi bwa NAD zirashobora no kugufasha kurwanya intambara zidakira zo mumutwe nko kwiheba, guhangayika, nizindi ndwara mbi.

Inyungu z'umubiri za NAD + kuvura

NAD rimwe na rimwe yitwa "umufasha wa molekile" kuko ihuza nindi misemburo ikanabafasha gukora akazi kabo neza.Ibibera muri selile yawe bigira itandukaniro rinini muburyo usa kandi wumva.Urutonde rwinyungu zumubiri ziva mubuvuzi bwa NAD ni ndende, kandi kimwe muribi byose bishobora kunoza ubuzima bwawe bwiza.

• Itezimbere ubuzima bwumutima
• Yongera imbaraga
• Yongera metabolism
• Kugabanya gucana
• Vuga gukira ibikomere
• Kugabanya ububabare
• Gukarisha amaso
• Kunoza kumva
• Kugabanya irari ry'ibintu byangiza
• Kugabanya ibimenyetso byo kwikuramo
• Ifasha kugabanya ibiro
• Irinda imitsi
• Itinda gusaza

Ikigaragara ni uko inyungu zo kuvura NAD zihagaze neza cyane mubuzima bwawe no kumererwa neza muri rusange, ndetse no kunoza ibimenyetso byindwara zimwe na zimwe zikomeye.

Kwigaerekana ko kuvura NAD bishobora kugabanya ibimenyetso byindwara ya Alzheimer.Nubwo impamvu nyayo itera indwara ya Alzheimer ikomeje kuba amayobera, tuzi ko irimo urupfu rw'uturemangingo ndetse n'imikorere mibi ya mitochondrial, byombi NAD ikemura.Byongeye kandi, imitekerereze ya neuroprotective ya NAD irashobora gufasha gukumira ibyangiritse mbere.