S-4 Niki (Andrarine)

S-4, yagurishijwe nkaandarine, ni umunwa bioavailable, non-steroidal selitori ya androgen reseptor modulator (SARM).Andarine nigice cya agonist ya reseptor ya androgene.

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Ifumbire ya S-4 yakoreshejwe mu bushakashatsi bw’inyamaswa ariko yaratereranywe mbere y’ikizamini cya mbere cy’amavuriro y’abantu, kubera ubumuga bwo kutabona.Izi ngaruka zibaho nkuko molekile ya S-4 ihuza reseptors mu jisho;uko gukaza umurego guhuza, niko bitagenda neza.Imvururu zagaragaye wasangaga zikunze kugaragara, kubera ibikorwa byihariye bya mehaniki, kubiyobyabwenge kuburyo ibigeragezo byatereranye.

NiguteS4Andarine Akazi

Bumwe mu buryo bwatanzwe bwaS4, ni uko ibuza rwose guhuza DHT.Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5α-DHT, androstanolone cyangwa stanolone) ni imisemburo ya endogenous androgene.Ugereranije na testosterone, DHT irakomeye cyane nka agonist ya reseptor ya androgene.

S-4 ifite reseptor nyinshi ya androgene (AR) ihuza isano.Ubushakashatsi bwerekanye ko S-4 idafite imbaraga kandi ikora neza kuruta testosterone propionate (TP) mubikorwa bya androgene, ariko ibikorwa byabo bya anabolike byari bisa cyangwa birenze ibya TP.

S-4 ni andorogene yuzuye ya reseptor agonist mubice byimitsi, hamwe na agonist igice muri prostate.Rero, S-4 itera imbaraga imikurire yimitsi, ariko ntishobora kugumana ubunini bwa prostate.Testosterone itera imitsi na prostate gukura kurwego rumwe.S-4 itera imisemburo ikomeye ya luteinizing (LH) cyangwa umusemburo utera imisemburo.

S-4 (andarine) Inyungu

Nubwo ubushakashatsi bwinshi bwakozwe, ubushakashatsi burakomeje kandi mubyiciro byambere byiterambere.Iterambere rya SARMS yo gukoresha ivuriro nubuvuzi nkuburyo bwa androgene, iratanga ikizere ishingiye kumibare yambere.

Bitandukanye na anabolike steroyide, ihuza reseptor ya androgene mu ngingo nyinshi z'umubiri, SARM ku giti cye ihitamo guhuza reseptor ya androgène mu ngingo zimwe na zimwe, ariko si mu zindi.Nubwo bimeze bityo, baracyerekana androgeneque na anabolike.

SARMS ntabwo ari anabolike steroid;ahubwo, ni ligande ya syntetique ihuza reseptor ya androgene.Ukurikije imiterere ya molekulari yabo, bakora nka agoniste, agoniste igice, na antagonist.Niyo mpamvu muburyo bwo guhitamo, SARMS ihindura cyangwa igahuza coregulators hamwe nimpamvu zandikirwa cyangwa ibimenyetso bya poroteyine za caskade kugirango biteze imbere ibikorwa bya anabolike.

Ubushakashatsi bwerekanye ko S-4 ari andorogene yuzuye ya reseptor agonist mumyanya yimitsi, hamwe na agonist igice muri prostate, bigatuma iba umukandida mwiza nkuburyo bwa steroidal androgene reseptor agonist (urugero, testosterone na DHT), kubera ingaruka mbi ziterwa nayo ku mwijima, umutima, n'uburumbuke.

Twabibutsa ko nubwo SARMS nka S4 yongera ibikorwa bya androgene, ntabwo ari umukandida ukomeye mu kuvura imisemburo ya hormone, kubera ko idahumura muri Estrogene.